Crossword clues for Is, to Isabella 4 lettersAnswerClueESTEIsabella d' ____ANOSYears in Isabella's reignESTEItaly's Isabella d'_____ESTAIsabella's "is"ESTEIsabella d'___ESTEIsabella d'___ (Titian subject)ESTEIsabella d'__ESTEIsabella d'___, Leonardo subjectMDIVYear Queen Isabella died.EMMAYounger sister of Isabella in a 19th-century novelRICAAffluent, to IsabellaESTEIsabella d'___, patron of LeonardoESTEIsabella d'___, poser for 46 AcrossESTAIs, to IsabellaMDIVYear of Isabella's deathESTAIs for IsabellaESTEIsabella d'___ (famed beauty)FERDQueen Isabella's man.ISABELLARuler who co-established the Spanish InquisitionISABELLAColumbus' backerISABELLASpanish queen who was given the title "the Catholic"ISABELLALongtime Lancome spokesmodel RosselliniISABELLAColumbus sponsorISABELLAFerdinand's queenISABELLAQueen who bankrolled ColumbusISABELLASponsor of explorer ChristopherISABELLACo-establisher of the Spanish InquisitionISABELLAColumbus' patronISABELLASponsor of ColumbusISABELLAColumbus' patron queenISABELLASponsor of a historic expeditionISABELLAMeasure for measure heroineISABELLAColumbus supporterISABELLAIngrid's acting daughterISABELLAChristopher's benefactressISABELLAHeroine of "Measure for Measure."ISABELLAThe patron of Columbus.ISABELLAA Bergman daughterISABELLAQueen who aided Columbus.ISABELLAColumbus' queenISABELLARoyal pawner of jewelsISABELLAFamous Queen of Castile.ISABELLATreaty of Tordesillas figureISABELLASponsor of 13 Across.ISABELLAConfident backer of Columbus.ISABELLABacker of Columbus.ISABELLALongtime Lancme spokesmodel RosselliniISABELLAChristopher's backerISABELLAQueen at the end of 51 Down's Reconquista periodISABELLA2009's top name for U.S. baby girls